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Hepatitis C Testing: A Complete Guide

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Testing

Hepatitis C Testing: A Complete Guide

References UK clinical guidance from the NHS, the British HIV Association (BHIVA), and the British Association for Sexual Health and HIV (BASHH). Last updated: April 2026.

Hepatitis C testing is a simple blood test that checks for the virus or antibodies to it. It’s important because hepatitis C often causes no symptoms for years but can silently damage the liver. Now that hepatitis C is curable in over 95% of cases with modern treatment, testing has real benefits — diagnosis leads straight to effective cure.

Here’s what to know.

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How Hepatitis C Testing Works

TestWhat It Shows
Anti-HCV antibody testPast or current exposure to hepatitis C
HCV RNA (PCR)Active current infection
Liver function testsWhether the liver is inflamed
FibroScanMeasures liver scarring

Who Should Test?

  • Anyone who has ever injected drugs
  • People with HIV
  • Men who have sex with men
  • People who had blood transfusions before 1991
  • People from countries with high hepatitis C rates
  • Sexual contacts of people with hepatitis C
  • People with unexplained liver problems

Where to Test

  • NHS sexual health clinics
  • Drug services and needle exchanges
  • GP surgery
  • Hepatology clinics
  • Home test kits with postal return

What Results Mean

Anti-HCV positive, RNA positive

You have active hepatitis C infection. Refer to hepatology for treatment — modern direct-acting antivirals cure over 95% of cases.

Anti-HCV positive, RNA negative

You were exposed to hepatitis C but have cleared the infection (either naturally or after successful treatment). No current infection.

Anti-HCV negative

No exposure — unless you tested within the window period (6 weeks to 3 months after exposure).

Window Period

  • Anti-HCV antibodies — usually detectable from 6 weeks to 3 months
  • HCV RNA — detectable earlier, from about 2 weeks after exposure

Treatment Benefits

Modern hepatitis C treatment:

  • Cures over 95% of people
  • Usually 8-12 weeks of tablets
  • Few side effects
  • Free on the NHS
  • Prevents long-term liver damage, cancer and transmission

If You Test Positive

  1. Confirmation testing
  2. Referral to hepatology
  3. Liver assessment
  4. Treatment with direct-acting antivirals
  5. Follow-up testing to confirm cure

Read more: Hepatitis B and C introduction | Hepatitis C survival | Hepatitis C and semen

Frequently Asked Questions

Is hepatitis C curable?

Yes. Modern treatment cures over 95% of cases.

Do I need to test if I have no symptoms?

If you have any risk factors, yes. Hepatitis C is often silent for years.

Is treatment free on the NHS?

Yes.

Sources

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