References UK clinical guidance from the NHS, the British HIV Association (BHIVA), and the British Association for Sexual Health and HIV (BASHH). Last updated: April 2026.
Valaciclovir (brand name Valtrex) is an antiviral medication used to treat genital herpes, cold sores and shingles. It’s a prodrug of aciclovir with better oral absorption, meaning it can be taken less frequently. Valaciclovir is used both for treating outbreaks and for daily suppressive therapy to reduce recurrence and transmission.
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Uses
| Condition | Typical Dose |
|---|---|
| Genital herpes (first episode) | 500mg twice daily for 5-10 days |
| Genital herpes (recurrence) | 500mg twice daily for 3-5 days |
| Suppressive therapy | 500mg once daily |
| Cold sores | 2g twice in one day |
| Shingles | 1g three times daily for 7 days |
Benefits of Suppressive Therapy
- Reduces outbreak frequency
- Reduces asymptomatic shedding
- Reduces transmission risk to partners
Side Effects
- Headache
- Nausea
- Generally well tolerated
Read more: What is herpes? | Aciclovir | Famvir
Frequently Asked Questions
Is valaciclovir better than aciclovir?
Similar effectiveness; valaciclovir needs fewer daily doses.
Can I take it long-term?
Yes — suppressive therapy is safe long-term.
Does it cure herpes?
No — it manages outbreaks and reduces transmission.
Related reading
- Can You Get Herpes From a Toilet Seat?
- Can You Get Herpes From Kissing?
- Comprehensive Test: Chlamydia, Gonorrhoea and Herpes
- Cold Sores vs Syphilis Sores: How to Tell the Difference
- Genital Warts vs Herpes: What's the Difference?
Sources
- NHS — Sexual health conditions
- BASHH — UK clinical guidelines for STI management
- British HIV Association (BHIVA) — HIV treatment guidelines
- Terrence Higgins Trust — sexual health information
- UK Health Security Agency — STI surveillance data
Steve Page is a recognised expert on Sexually Transmitted Diseases (STDs) and STD treatments, having published numerous articles in peer-reviewed journals and presented his research at conferences around the world. He has an in-depth understanding of the latest medical research on STDs, and is an advocate for the development of new treatments and protocols to improve the health of those affected. In addition to his research, he has dedicated his career to understanding the causes and symptoms of STDs, as well as how to best treat those impacted.
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