References UK clinical guidance from the NHS, the British HIV Association (BHIVA), and the British Association for Sexual Health and HIV (BASHH). Last updated: April 2026.
Fluconazole is an antifungal medication widely used to treat thrush (candidiasis). A single 150mg capsule is the standard treatment for uncomplicated vaginal thrush. It’s available from pharmacies without prescription for mild cases and works by killing the Candida yeast that causes the infection.
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Common Uses
| Condition | Dose |
|---|---|
| Vaginal thrush | Single 150mg capsule |
| Penile thrush | 150mg capsule |
| Oral thrush | 50-100mg daily for 7-14 days |
| Recurrent thrush | Weekly or monthly maintenance |
Side Effects
- Nausea
- Headache
- Abdominal discomfort
- Rarely: liver effects
When to See a Doctor
- First episode (confirm diagnosis)
- Pregnancy
- Recurring infections
- Symptoms not improving
Read more: Diflucan | What is thrush? | Thrush or STI?
Frequently Asked Questions
Can I buy fluconazole without prescription?
Yes for uncomplicated vaginal thrush.
How fast does it work?
Usually 1-3 days.
Is it safe with HIV medication?
Generally yes — check with your pharmacist.
Related reading
- Using Antibiotics to Prevent STIs: DoxyPEP Explained
- Azithromycin: Uses in Sexual Health
- Best Antibiotics for STIs: A Practical Guide
- Ciprofloxacin for STIs: Uses, Dosage, and Side Effects
- Clindamycin: Uses in Sexual Health
Sources
- NHS — Sexual health conditions
- BASHH — UK clinical guidelines for STI management
- British HIV Association (BHIVA) — HIV treatment guidelines
- Terrence Higgins Trust — sexual health information
- UK Health Security Agency — STI surveillance data

Steve Page is a recognised expert on Sexually Transmitted Diseases (STDs) and STD treatments, having published numerous articles in peer-reviewed journals and presented his research at conferences around the world. He has an in-depth understanding of the latest medical research on STDs, and is an advocate for the development of new treatments and protocols to improve the health of those affected. In addition to his research, he has dedicated his career to understanding the causes and symptoms of STDs, as well as how to best treat those impacted.
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