What is Mycoplasma Genitalium?

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By Steve Page

Mycoplasma genitalium, or Mgen, is a sexually transmitted bacterial infection. This pathogenic bacterium inhabits the mucous epithelial cells of humans.

According to Medical reports, this condition is becoming increasingly common. It can be transmitted from one individual to another, and it is important to identify high-risk populations to prevent infection. Read on to learn more about the symptoms, diagnosis, and treatment of Mycoplasma genitalium.

Sexually transmitted infection

Mycoplasma genitalium (Mgen) is a common STI. About 7-8% of affected men and women don’t show any signs of infection. Most people have no symptoms, although it is possible to develop pelvic inflammatory disease or nongonococcal urethritis after sexual contact. Cervicitis is another symptom of Mgen, and can lead to pain during intercourse or discharge afterward.

The role of Mycoplasma genitalium as an STI is unclear. Infection with the bacterium is often asymptomatic, and its relationship to a wide range of other diseases is less well understood. Its symptoms may include ectopic pregnancy, post-partum infections, pelvic inflammatory disease, mucopurulent cervicitis, and tubal factor infertility.

Currently, M genitalium testing is justified for women who have genital symptoms. It is also associated with cervicitis, endometritis, and clinical pelvic inflammatory disease. However, further studies are needed to determine the best way to test asymptomatic women for M genitalium. If asymptomatic women are sexually active, they should be tested as soon as possible for M genitalium.

Causes of urethritis

Mycoplasma genitalium, a bacteria, is a common cause of nongonococcal urethritis. This disease was first observed in 1980 in two men. Since then, it has been found to cause several different syndromes. A recent study found that this organism is the cause of recurrent nongonococcal urethritis and has been associated with an increased risk of recurrence.

Researchers have discovered that Mycoplasma genitalium is more resistant to antibiotics than other bacteria that cause urethritis. This is the primary reason why this infection is resistant to macrolides. However, there are other reasons why a person may contract this disease. For example, a person may develop urethritis because of infection with a sexually transmitted infection.

A recent meta-analysis has shown a link between M. genitalium and urethritis in men. In this meta-analysis of 37 studies, M. genitalium was associated with a pooled OR of 5.5 for NGU and 7.6 for NCNGU. The prevalence of M. genitalium in men with NGU is between 10 percent and 35 percent, contributing to the overall burden of the disease. In the general population, M. genitalium is present in one percent to three percent of men.


Antibiotic medication is the most common treatment for Mycoplasma genitalium. Doxycycline is the first line treatment and is taken twice daily for seven days. Azithromycin is the second line treatment and is taken in one dose of 500 mg twice a day for two days. The effectiveness of these antimicrobial agents depends on their effectiveness in inhibiting protein synthesis. The bacterial ribosomes are highly susceptible to these drugs, and a complete course can result in a cure.

Symptoms of Mycoplasma genitalium may include inflammatory lesions of the penis and foreskin. Other common complications include infection of the urethra, which results in pain during urination. Cervicitis, on the other hand, is an infection of the cervix, which can lead to bleeding and discharge after intercourse. A combination of medications is sometimes necessary for proper Mycoplasma genitalium treatment.

High-risk populations

The prevalence of M. genitalium was higher among black and non-Hispanic subjects compared with white subjects, and in males, compared with females. This finding is consistent with previous reports that found the prevalence of M. genitalium to be two to three times higher in these populations. However, it is important to note that M. genitalium infection rates were lower among Hispanics than in non-Hispanic or white females.

In China, high-risk populations of mycoplasma gnu are at an increased risk for acquiring the bacterium. In a population-based study, the prevalence of Mycoplasma genitalium was 1.95%. These results suggest that the infection is largely asymptomatic in healthy women. However, infection rates are higher in people who smoke, are undergoing chemotherapy, or have a history of pelvic inflammatory disease.